Which components primarily constitute chromatin within the cell nucleus?

A DNA along with histone proteins

B RNA and non-histone proteins

C Lipids and structural proteins

D Carbohydrates and nucleotides

Solution

Correct Answer: Option A

Chromatin is the complex of genetic material and proteins found within the cell nucleus. Its primary components are DNA and histone proteins. The DNA carries the genetic code, while histones act as spool-like proteins around which DNA is tightly wrapped. This packaging helps to efficiently condense the long DNA molecules, facilitating organization, protection, and regulation of gene expression within the nucleus.

- DNA: The long polymer of nucleotides that contains the hereditary information.
- Histone proteins: Positively charged proteins that bind to negatively charged DNA, helping to form nucleosomes — the fundamental units of chromatin structure.

Other components such as RNA and non-histone proteins may be associated with chromatin but are not the primary structural constituents. Lipids and carbohydrates are not involved in chromatin structure.

Therefore, the correct answer is: Option 1: DNA along with histone proteins.

Reference: Gray’s Anatomy, 41st Edition, Volume 2, Chapter: Cell Nucleus and Chromatin Structure, Page 325

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