Which of the following karyotypes corresponds to Turner syndrome?
Solution
Correct Answer: Option C
The karyotype that corresponds to Turner syndrome is 45,X.
- Turner syndrome is a genetic condition that affects females and is characterized by the complete or partial absence of one X chromosome. Normally, females have two X chromosomes (46,XX), but in Turner syndrome, affected individuals have only a single X chromosome, resulting in a 45,X karyotype. This chromosomal anomaly leads to a variety of clinical features including short stature, gonadal dysgenesis (underdeveloped ovaries), infertility, and certain physical characteristics such as a webbed neck and lymphedema.
To clarify the other options:
- 46,XX represents a normal female karyotype.
- 47,XXY corresponds to Klinefelter syndrome, a condition in males where there is an extra X chromosome.
- 46,XY represents a normal male karyotype.
Reference: Robbins Basic Pathology, 10th Edition, Chapter 20: Genetic Disorders / Page 180-182