Which of the following karyotypes corresponds to Turner syndrome?

A 46,XX

B 47,XXY

C 45,X

D 46,XY

Solution

Correct Answer: Option C

The karyotype that corresponds to Turner syndrome is 45,X.

- Turner syndrome is a genetic condition that affects females and is characterized by the complete or partial absence of one X chromosome. Normally, females have two X chromosomes (46,XX), but in Turner syndrome, affected individuals have only a single X chromosome, resulting in a 45,X karyotype. This chromosomal anomaly leads to a variety of clinical features including short stature, gonadal dysgenesis (underdeveloped ovaries), infertility, and certain physical characteristics such as a webbed neck and lymphedema.

To clarify the other options:
- 46,XX represents a normal female karyotype.
- 47,XXY corresponds to Klinefelter syndrome, a condition in males where there is an extra X chromosome.
- 46,XY represents a normal male karyotype.

Reference: Robbins Basic Pathology, 10th Edition, Chapter 20: Genetic Disorders / Page 180-182

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