The Goldman-Hodgkin-Katz equation is primarily used to calculate:
Solution
Correct Answer: Option A
- The Goldman-Hodgkin-Katz (GHK) equation is a fundamental tool in understanding the electrical properties of cell membranes.
- Unlike the Nernst equation, which calculates the equilibrium potential for a single ion species, the GHK equation takes into account the relative permeabilities and concentrations of multiple ions simultaneously.
- This makes it particularly useful for determining the resting membrane potential of cells where ions like potassium (K⁺), sodium (Na⁺), and chloride (Cl⁻) all contribute to the electrical charge across the membrane.
- The GHK equation mathematically integrates these factors, providing a more accurate and physiologically relevant value for the membrane potential when several ion species permeate the membrane.
- Therefore, it reflects the combined effect of various ions rather than focusing on just one ion as individual equilibrium potentials do.
In summary, the GHK equation is primarily used to calculate the resting membrane potential incorporating multiple ion permeabilities, making Option 1 the correct choice.
- Unlike the Nernst equation, which calculates the equilibrium potential for a single ion species, the GHK equation takes into account the relative permeabilities and concentrations of multiple ions simultaneously.
- This makes it particularly useful for determining the resting membrane potential of cells where ions like potassium (K⁺), sodium (Na⁺), and chloride (Cl⁻) all contribute to the electrical charge across the membrane.
- The GHK equation mathematically integrates these factors, providing a more accurate and physiologically relevant value for the membrane potential when several ion species permeate the membrane.
- Therefore, it reflects the combined effect of various ions rather than focusing on just one ion as individual equilibrium potentials do.
In summary, the GHK equation is primarily used to calculate the resting membrane potential incorporating multiple ion permeabilities, making Option 1 the correct choice.
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