- The organ primarily responsible for detoxification in the human body is the liver.
- The liver plays a crucial role in metabolizing and breaking down various toxins, drugs, and harmful substances that enter the body.
- It contains specialized enzymes, such as the cytochrome P450 family, which facilitate the chemical reactions necessary to convert lipophilic toxins into water-soluble compounds that can be easily excreted.

- While the kidneys also contribute to eliminating waste products by filtering the blood and excreting urine, they mainly handle water-soluble substances and are not directly involved in metabolizing toxins.

- The lungs are primarily responsible for gas exchange, removing carbon dioxide from the bloodstream, but they do not perform detoxification.

- The spleen is involved in filtering blood and immune system functions but is not a detoxifying organ.

Therefore, the liver is the central detoxification organ in the body.

Reference: Guyton and Hall Textbook of Medical Physiology, 14th Edition, Chapter 25/Pages 324-327