- Chronic alcohol use is frequently associated with various electrolyte disturbances, but the most common deficiency responsible for generalized seizures in this context is magnesium deficiency.

- Magnesium plays a critical role in neuromuscular excitability and acts as a natural calcium antagonist at the neuronal level.
- A deficiency in magnesium leads to increased neuronal excitability, which can precipitate seizures.
- Additionally, chronic alcohol consumption causes poor dietary intake, gastrointestinal losses, renal wasting, and impaired magnesium absorption, all contributing to hypomagnesemia.

- While other electrolytes such as calcium, potassium, and sodium can also be abnormal in alcoholics, magnesium deficiency is the most directly linked to seizure activity in this population.

Therefore, in a patient with chronic alcohol use presenting with seizures, it is crucial to assess and correct magnesium levels promptly to prevent and manage seizures effectively.

Reference: Harrison's Principles of Internal Medicine, 20th Edition, Volume 1, Chapter 295, Page 2094