Which of the following is the primary function of Sertoli cells in the testes?
Solution
Correct Answer: Option B
- The primary function of Sertoli cells in the testes is to provide support and nourishment to developing sperm cells.
- These cells are often referred to as "nurse cells" because they play a crucial role in the process of spermatogenesis, which is the formation and development of spermatozoa.
- Sertoli cells create a specialized microenvironment by forming the blood-testis barrier, which protects germ cells from harmful substances and immune attacks.
- They also secrete various substances such as nutrients, growth factors, and androgen-binding protein that are essential for the maturation of sperm cells.
- While Sertoli cells do produce inhibin, which helps regulate follicle-stimulating hormone (FSH) levels, this is considered a secondary function rather than their primary role.
- On the other hand, Leydig cells in the testes are responsible for the secretion of testosterone (Option 1), and hormones like luteinizing hormone (LH) are synthesized by the anterior pituitary gland, not the Sertoli cells (Option 4).
In summary, the correct answer is: Support and nourishment of developing sperm cells
Reference: Ganong's Review of Medical Physiology, 26th Edition, Chapter 22: Male Reproductive Physiology
- These cells are often referred to as "nurse cells" because they play a crucial role in the process of spermatogenesis, which is the formation and development of spermatozoa.
- Sertoli cells create a specialized microenvironment by forming the blood-testis barrier, which protects germ cells from harmful substances and immune attacks.
- They also secrete various substances such as nutrients, growth factors, and androgen-binding protein that are essential for the maturation of sperm cells.
- While Sertoli cells do produce inhibin, which helps regulate follicle-stimulating hormone (FSH) levels, this is considered a secondary function rather than their primary role.
- On the other hand, Leydig cells in the testes are responsible for the secretion of testosterone (Option 1), and hormones like luteinizing hormone (LH) are synthesized by the anterior pituitary gland, not the Sertoli cells (Option 4).
In summary, the correct answer is: Support and nourishment of developing sperm cells
Reference: Ganong's Review of Medical Physiology, 26th Edition, Chapter 22: Male Reproductive Physiology
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