Which structural protein is primarily responsible for rendering the skin impermeable to water?
Solution
Correct Answer: Option B
The structural protein primarily responsible for rendering the skin impermeable to water is Keratin.
- Keratin is a fibrous protein found in the epidermis, the outermost layer of the skin.
- It plays a crucial role in forming a protective barrier against environmental damage, including preventing water loss and entry of harmful substances.
- The skin’s ability to resist water permeability largely depends on the accumulation of keratin within keratinocytes, which become keratinized and form a tough, insoluble layer known as the stratum corneum.
To contrast:
- Elastin provides elasticity to the skin but does not contribute to water impermeability.
- Collagen provides structural strength and support in the dermis but is not involved in preventing water loss.
- Fibronectin is involved in cell adhesion and wound healing, but does not contribute to the skin’s waterproof barrier.
Thus, keratin is essential for creating the skin’s water-resistant barrier, maintaining proper hydration, and protecting underlying tissues.
Reference: Robbins Basic Pathology, 10th Edition, Chapter 3: Skin
- Keratin is a fibrous protein found in the epidermis, the outermost layer of the skin.
- It plays a crucial role in forming a protective barrier against environmental damage, including preventing water loss and entry of harmful substances.
- The skin’s ability to resist water permeability largely depends on the accumulation of keratin within keratinocytes, which become keratinized and form a tough, insoluble layer known as the stratum corneum.
To contrast:
- Elastin provides elasticity to the skin but does not contribute to water impermeability.
- Collagen provides structural strength and support in the dermis but is not involved in preventing water loss.
- Fibronectin is involved in cell adhesion and wound healing, but does not contribute to the skin’s waterproof barrier.
Thus, keratin is essential for creating the skin’s water-resistant barrier, maintaining proper hydration, and protecting underlying tissues.
Reference: Robbins Basic Pathology, 10th Edition, Chapter 3: Skin
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