Which cell type predominantly constitutes the cellular component of connective tissue proper?

A Fibroblasts

B Macrophages

C Mast cells

D Chondrocytes

Solution

Correct Answer: Option A

- The cellular component of connective tissue proper is predominantly composed of fibroblasts.
- These cells play a crucial role in maintaining and synthesizing the extracellular matrix, which includes collagen, elastin, and ground substance.
- Fibroblasts are responsible for producing the fibers and ground substance that provide strength, support, and elasticity to the connective tissue.

- While macrophages and mast cells are also present within connective tissue proper, their roles are more specialized. Macrophages function primarily in phagocytosis and immune defense, and mast cells are involved in inflammatory responses and allergic reactions.
- On the other hand, chondrocytes are specific to cartilage tissue, not connective tissue proper.

In summary:
- Fibroblasts are the most abundant and essential cells in connective tissue proper.
- They synthesize and maintain the extracellular fibers and ground substance.
- Other cells like macrophages and mast cells have supportive and immune roles but are less numerous.
- Chondrocytes are exclusive to cartilage and do not constitute connective tissue proper.

Reference: Ross and Pawlina, Histology: A Text and Atlas, 8th Edition, Chapter 4: Connective Tissue

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