- The primary adverse effect associated with bisphenol A (BPA) found in dental materials is its estrogenic activity.
- BPA is a synthetic compound used in the manufacture of certain dental resins and sealants.
- Although BPA itself is not directly added to dental products, trace amounts can be released as a byproduct or monomer in composite resins and sealants.

- The key concern with BPA exposure is its ability to mimic the hormone estrogen, leading to endocrine disruption.
- This estrogenic activity can potentially interfere with normal hormonal function, which is especially concerning in vulnerable populations such as children and pregnant women.
- While the levels of BPA exposure from dental materials are generally low and considered safe by regulatory agencies, the cumulative exposure from various sources may pose health risks.

- In contrast, mutagenic potential, neurotoxicity, and allergic contact dermatitis are not the primary concerns with BPA in dental materials. Although allergic reactions may occur with some dental materials, BPA's main documented adverse property relates to its hormone-like effects.

Summary:
- BPA exhibits estrogenic activity, acting as an endocrine disruptor.
- This effect is the primary adverse concern in dentistry regarding BPA.
- Exposure from dental materials is low but should be considered in the context of overall exposure.