- The primary concern associated with the use of formocresol in pediatric pulpotomy procedures is its potential carcinogenic and mutagenic effects.
- Formocresol, a combination of formaldehyde and cresol, has been widely used due to its effective antimicrobial properties and ability to fix pulpal tissue.
- However, formaldehyde, a key component, is recognized as a potential carcinogen and has been linked to mutagenic changes in cells.

- While formocresol is effective in controlling infection and preserving the remaining pulp tissue, long-term safety concerns have led to a decline in its use, especially in pediatric dentistry.
- Alternatives such as Mineral Trioxide Aggregate (MTA) and other biocompatible materials are increasingly preferred due to their favorable safety profiles.

Other options like allergic reactions and tooth discoloration are less significant concerns compared to the systemic and cellular toxicity associated with formocresol.

Key points:
- Formocresol contains formaldehyde, a recognized carcinogen.
- Potential mutagenic effects can affect cellular DNA.
- Long-term safety concerns have reduced its popularity in pediatric dentistry.
- Alternative materials with better biocompatibility are now preferred.

Reference: Robinson’s Current Therapy in Pediatric Dentistry, Volume 1, Chapter 8, Page 156