- Fatty change refers to the abnormal accumulation of lipids (triglycerides) within the cytoplasm of parenchymal cells, typically seen in organs like the liver, heart, and kidneys.
- This occurs due to impaired lipid metabolism or excessive lipid uptake.
- It is distinct from other degenerations because it involves intracellular fat droplets, making cells appear vacuolated under the microscope.
- Unlike hyaline, mucoid, or amyloid degeneration, which involve proteinaceous or mucopolysaccharide deposits, fatty change specifically involves lipid accumulation.

Reference: Robbins Basic Pathology, 10th Edition, Chapter 2, Cellular Injury and Adaptations