- The development of colon cancer from benign adenomatous polyps exemplifies multistep carcinogenesis because it involves the sequential accumulation of genetic mutations that drive the progression from normal epithelium to adenoma to carcinoma.
- This process highlights the gradual transformation requiring multiple hits, including activation of oncogenes and loss of tumor suppressor genes.
- It contrasts with concepts like field cancerization or clonal expansion, which refer to different mechanisms of tumor development or spread.

Reference: Robbins Basic Pathology, 10th Edition, Chapter 7, Page 279