Bruton's agammaglobulinemia is primarily caused by a defect in which of the following processes?
Solution
Correct Answer: Option C
- Bruton's agammaglobulinemia is caused by a mutation in the BTK gene, which is crucial for B-cell development.
- This defect leads to a block in B-cell maturation, resulting in a marked reduction or absence of mature B cells and consequently very low levels of all immunoglobulin classes.
- Because T-cell maturation, complement activation, and phagocytosis remain intact, the primary problem lies in B-cell development impairing humoral immunity.
Reference: Kelley’s Textbook of Internal Medicine, Volume 2, Chapter on Immunodeficiencies, p. 1345
- This defect leads to a block in B-cell maturation, resulting in a marked reduction or absence of mature B cells and consequently very low levels of all immunoglobulin classes.
- Because T-cell maturation, complement activation, and phagocytosis remain intact, the primary problem lies in B-cell development impairing humoral immunity.
Reference: Kelley’s Textbook of Internal Medicine, Volume 2, Chapter on Immunodeficiencies, p. 1345
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