- The characteristic rose spots in typhoid fever typically appear during the 2nd week of illness.
- This timing corresponds to the period when bacterial invasion of Peyer’s patches and subsequent bacteremia cause skin manifestations.
- Rose spots are small, pink, blanching maculopapular lesions primarily found on the trunk.
- Their appearance aligns with the host's immune response and bacterial dissemination phase in the disease course.

Reference: Harrison's Principles of Internal Medicine, 20th Edition, Infectious Diseases, Chapter on Typhoid Fever