Which clinical feature distinguishes shigellosis from cholera?

A Profuse watery diarrhea without blood

B Presence of bloody diarrhea

C Severe vomiting and dehydration

D Rice-water stools

Solution

Correct Answer: Option B

- The key clinical difference is that shigellosis causes invasive colitis, leading to inflammation and ulceration of the intestinal mucosa, which results in bloody diarrhea (dysentery).
- In contrast, cholera is a non-invasive infection caused by Vibrio cholerae, characterized by the secretion of a toxin that induces profuse watery diarrhea without blood.

Thus, presence of bloody diarrhea distinguishes shigellosis from cholera.

Reference: Robbins Basic Pathology, 10th Edition, Chapter 13 / Page 545

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