Which of the following clinical manifestations is most characteristic of disseminated gonococcal infection (DGI)?

A Arthritis-dermatitis syndrome

B Meningitis with cranial nerve palsies

C Hemorrhagic cystitis

D Necrotizing fasciitis

Solution

Correct Answer: Option A

- The correct answer is Arthritis-dermatitis syndrome because it is the classic presentation of disseminated gonococcal infection (DGI).
- This syndrome typically includes polyarthralgia or migratory arthritis, along with characteristic pustular skin lesions.
- DGI results from hematogenous spread of Neisseria gonorrhoeae. Other options like meningitis, cystitis, or necrotizing fasciitis are not typical manifestations of DGI.

Reference: Harrison's Principles of Internal Medicine, 20th Edition, Infectious Diseases Chapter

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