- The recommended first-line treatment for uncomplicated gonococcal infection is Ceftriaxone plus Azithromycin because ceftriaxone effectively targets Neisseria gonorrhoeae with high efficacy and azithromycin covers potential concurrent chlamydial infection and may help prevent resistance.
- Monotherapy is discouraged due to increasing antibiotic resistance.
- Alternatives like doxycycline alone or penicillin G are not appropriate due to resistance and suboptimal efficacy. Metronidazole and ciprofloxacin are not effective against gonorrhea.

Reference: Harrison’s Principles of Internal Medicine, 20th Edition, Infectious Diseases, Chapter 133