Which of the following cells is chiefly involved in the secretion of antibodies during an immune response?

- The correct answer is Plasma cell because these cells are the terminally differentiated B cells responsible for producing and secreting large amounts of antibodies during an immune response.
- Antibodies bind to specific antigens to neutralize pathogens or mark them for destruction.
- In contrast, T helper cells assist in activating B cells, macrophages engulf pathogens, and dendritic cells present antigens to initiate immune responses.
- Thus, the primary role of antibody secretion is uniquely attributed to plasma cells.

Reference: Janeway's Immunobiology, 9th Edition, Chapter 6, Page 250