Which primary immunodeficiency is caused by a defect in the NADPH oxidase enzyme complex?
Solution
Correct Answer: Option B
- Chronic Granulomatous Disease (CGD) is caused by a defect in the NADPH oxidase enzyme complex, which is essential for producing reactive oxygen species in phagocytes.
- This defect impairs the respiratory burst, leading to an inability to kill certain bacteria and fungi effectively.
- As a result, patients with CGD develop recurrent infections and granuloma formation.
Other options involve defects in different immune mechanisms and are not related to NADPH oxidase.
- This defect impairs the respiratory burst, leading to an inability to kill certain bacteria and fungi effectively.
- As a result, patients with CGD develop recurrent infections and granuloma formation.
Other options involve defects in different immune mechanisms and are not related to NADPH oxidase.
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