Which of the following microaerophilic bacteria is primarily responsible for the development of peptic ulcers?

A Helicobacter pylori

B Escherichia coli

C Vibrio cholerae

D Clostridium difficile

Solution

Correct Answer: Option A

- Helicobacter pylori is a microaerophilic bacterium that colonizes the acidic environment of the stomach.
- It produces urease enzyme, which neutralizes stomach acid by converting urea to ammonia, allowing it to survive and damage the gastric mucosa.
- This damage leads to inflammation and ulcer formation, making H. pylori the primary cause of peptic ulcers.
- Other bacteria listed do not colonize or affect the stomach lining in this way.

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