Hepatitis B virus (HBV) is a DNA virus that integrates into the host genome, causing chronic liver inflammation and cellular damage. This persistent injury leads to fibrosis, cirrhosis, and ultimately hepatocellular carcinoma (HCC). HBV's direct oncogenic effect through viral proteins like HBx also promotes hepatic carcinogenesis. Other viruses listed do not primarily infect hepatocytes or cause this cancer type.

Reference: *Robbins & Cotran Pathologic Basis of Disease*, 10th Edition, Volume 2, Chapter 18, pp. 1104-1106.