- The use of narrow-spectrum antibiotics whenever feasible is fundamental to rational prescribing as it targets the specific causative organism, minimizing disruption to normal flora and reducing the risk of antibiotic resistance.
- Broad-spectrum antibiotics should be reserved for cases where the pathogen is unknown or polymicrobial infections are suspected.
- Selective use helps to preserve the efficacy of antibiotics, reduce side effects, and decreases the emergence of resistant strains.
- Rational prescribing based on culture and sensitivity data is essential for effective and safe treatment.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Infectious Diseases, Page 678.