- The primary objective of rational antibiotic prescribing is to optimize patient clinical outcomes by ensuring effective eradication of infection while minimizing potential harm.
- This involves selecting the appropriate antibiotic, dose, route, and duration based on the identified or suspected pathogen and patient factors.
- While minimizing resistance and controlling costs are important, the foremost goal remains achieving the best clinical response for the individual patient, preventing complications and mortality.
- Rational use also helps preserve antibiotic efficacy for future patients but only as a secondary benefit when aligned with optimal care.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Infectious Diseases, Page 723.