- The primary mode of transmission for Entamoeba histolytica is the fecal-oral route, typically through ingestion of cysts in contaminated food or water.
- These cysts are resistant to gastric acid and excyst in the intestines, leading to infection.
- Direct person-to-person transmission occurs via poor sanitation and hygiene.
- Respiratory, skin contact, or vector-borne routes are not involved in the spread of this protozoan.
- Controlling sanitation and safe water supplies is crucial to prevent transmission.

Reference: Davidson’s Principles and Practice of Medicine, 24th Edition, Chapter: Infectious Diseases, Page 676.