- The group most commonly at risk of acquiring amoebiasis is travelers visiting endemic regions, as amoebiasis is primarily transmitted via the fecal-oral route in areas with poor sanitation and contaminated water.
- These travelers are exposed to Entamoeba histolytica in endemic tropical and subtropical regions, where the parasite is prevalent.
- Immunocompromised patients and healthcare workers may be at risk for various infections, but amoebiasis is particularly associated with environmental exposure in endemic areas rather than hospital or urban settings.
- Therefore, the greatest risk arises during travel to these regions.

Reference: Davidson’s Principles and Practice of Medicine, 24th Edition, Chapter: Gastrointestinal infections, Page 822.