- Hypopigmented skin patches are a characteristic manifestation of leprosy due to the loss of melanin pigmentation from nerve damage and skin infiltration by Mycobacterium leprae, leading to areas with diminished sensation.
- These patches are typically dry, hairless, and anaesthetic, which helps differentiate leprosy from other dermatoses.
- This clinical feature is important in early diagnosis and management of the disease.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Infections of the Skin and Subcutaneous Tissue, Page 976.