- Zinc supplementation has been shown to significantly reduce the duration, severity, and recurrence of diarrheal episodes in children, thereby decreasing mortality.
- It enhances intestinal mucosal repair, immune function, and enzyme activity, which helps in faster recovery.
- Unlike oral rehydration therapy, which primarily prevents death by managing dehydration, zinc directly influences the disease process and long-term outcomes.
- Large-scale trials have confirmed that routine zinc supplementation during acute diarrhea reduces the risk of future episodes and mortality in pediatric patients.

Reference: Davidson’s Principles and Practice of Medicine, 24th Edition, Chapter: Diarrhoeal Diseases, Page 679.