- In patients presenting with fever after recent travel to a malaria-endemic region, Plasmodium falciparum is the most common and clinically significant cause due to its high prevalence and potential for severe disease.
- It is responsible for the majority of cases of complicated malaria, characterized by high parasitemia, cerebral involvement, and multi-organ failure. Rapid diagnosis and treatment are crucial to reduce mortality.
- Unlike other Plasmodium species, P. falciparum has a shorter erythrocytic cycle and can infect red blood cells of all ages, resulting in higher parasite loads and more severe symptoms.

Reference: Davidson’s Principles and Practice of Medicine, 24th Edition, Chapter: Malaria, Page 1012.