- Hepatitis A vaccine is an effective preventive strategy against viral hepatitis presenting with jaundice because it induces protective immunity against Hepatitis A virus (HAV), which commonly causes acute viral hepatitis with jaundice.
- Vaccination interrupts transmission by generating long-lasting antibodies, thereby preventing infection.
- In contrast, therapies like ribavirin, intravenous immunoglobulin, or lamivudine are used for treatment or post-exposure management but do not serve as primary preventive measures.
- Therefore, active immunization with Hepatitis A vaccine is the most effective method to prevent Hepatitis A infection and its clinical manifestations such as jaundice.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Diseases of the Liver, Page 691.