- In hemolytic anemia, there is premature destruction of red blood cells, leading to increased demand for erythropoiesis.
- The bone marrow responds by releasing more immature red cells, known as reticulocytes, into the bloodstream, resulting in an elevated reticulocyte count.
- This is a key laboratory marker indicating the bone marrow’s compensatory response to anemia.
- It helps differentiate hemolytic anemia from other causes of anemia where reticulocyte production is inadequate.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Disorders of Red Blood Cells, Page 278.