- The most effective intervention to prevent the development of ascites in patients with viral hepatitis is Hepatitis B vaccination, as it prevents the initial infection or chronic progression of hepatitis B, thereby reducing the risk of liver cirrhosis and subsequent ascites formation.
- Therapeutic measures like diuretics, paracentesis, or sodium restriction are aimed at managing ascites once it has developed, not preventing its occurrence.
- Preventing chronic hepatitis through vaccination directly interrupts the disease process at an early stage, thereby significantly lowering the incidence of complications such as ascites.

Reference: Davidson’s Principles and Practice of Medicine, 24th Edition, Chapter: Diseases of the Liver and Biliary System, Page 755.