- Lipase is the most specific serum enzyme for diagnosing acute pancreatitis because it is produced primarily by the pancreas and remains elevated longer than amylase, allowing for a wider diagnostic window.
- Unlike amylase, lipase levels are less influenced by non-pancreatic conditions such as salivary gland disorders or intestinal diseases.
- Elevated serum lipase reflects pancreatic injury with higher sensitivity and specificity, making it the preferred biochemical marker in clinical practice.
- This specificity aids in distinguishing pancreatitis from other abdominal pathologies presenting with similar symptoms.

Reference: Davidson’s Principles and Practice of Medicine, 23rd Edition, Chapter: Disorders of the pancreas, Page 843.