McBurney's point is clinically significant as it marks the most tender spot in acute appendicitis, corresponding to the base of the appendix. Anatomically, it is located at one-third the distance from the anterior superior iliac spine (ASIS) to the umbilicus. This specific location approximates the position where the appendix is attached to the cecum, guiding surgeons in making a muscle-splitting incision for appendectomy. Identifying this point minimizes tissue damage and allows direct access to the inflamed appendix. Hence, palpation at this precise landmark aids in diagnosis and surgical planning.

Reference: Bailey & Love’s Short Practice of Surgery, 27th Edition.