The mesiobuccal canal in maxillary molars is most commonly known to bifurcate, often presenting a second canal referred to as MB2. This anatomical variation is clinically significant because missing the MB2 canal during endodontic treatment can lead to treatment failure. The MB2 canal is typically located mesiopalatally to the main mesiobuccal canal and may require enhanced visualization techniques such as magnification and careful exploration. Recognizing and properly instrumenting this canal improves the success rate of root canal therapy in maxillary molars.

Reference: Cohen's Pathways of the Pulp, 12th Edition.