The first public demonstration of ether anesthesia was successfully performed at Massachusetts General Hospital in 1846. This landmark event showcased the ability to perform surgery without pain, revolutionizing surgical practice. The demonstration was conducted by dentist William T.G. Morton, who used ether as an effective inhalational anesthetic agent. This event established ether anesthesia as a safe and reliable method for inducing surgical anesthesia, greatly improving patient outcomes and expanding the possibilities of operative procedures. The successful use of ether at Massachusetts General Hospital remains a cornerstone in the history of anesthesia.

Reference: Miller’s Anesthesia, 9th Edition.