Biofilms in chronic wounds are clinically significant because they consist of bacterial communities encased in a protective extracellular matrix. This matrix shields bacteria from antibiotics and the host immune response, leading to persistent infections. Consequently, biofilms increase antibiotic resistance, making infections harder to eradicate and delaying wound healing. Recognizing and addressing biofilms is crucial for effective wound management and improved patient outcomes.

Reference: Wound Care Essentials: Practice Principles, 5th Edition.