The principle of Autonomy is paramount in end-of-life care as it respects the patient's right to make informed decisions about their own treatment and bodily integrity. This includes the choice to accept or refuse life-sustaining interventions based on personal values and preferences. Upholding autonomy ensures that care aligns with the patient's wishes, promoting dignity and self-determination at the end of life. Other principles are important but secondary to honoring the patient’s own decisions.

Reference: Medical Ethics: Principles and Practice, 3rd Edition.