The most common cause of paraphimosis is iatrogenic, typically resulting from improper handling of the foreskin during catheterization, examination, or surgical procedures. Failure to reposition the retracted foreskin back over the glans after such manipulations leads to constriction and edema, causing paraphimosis. Prompt recognition and reduction are critical to prevent ischemic complications. Proper surgical technique mandates that the foreskin should always be returned to its natural position post-procedure to avoid this preventable condition.

Reference: Campbell-Walsh Urology, 12th Edition.