Untreated osteomyelitis frequently leads to the formation of a bone abscess due to the accumulation of pus within the bone tissue. This occurs as the infection progresses, causing localized bone necrosis and sequestrum formation. The abscess creates a sequestrated area resistant to antibiotic penetration, necessitating surgical debridement to remove necrotic bone and drain the pus. Failure to address the abscess results in persistent infection and further bone destruction. Recognizing and managing bone abscess is critical to prevent chronic osteomyelitis and systemic spread.

Reference: Campbell-Walsh Urology, 12th Edition.