Peptic ulcer-related gastric outlet obstruction occurs due to fibrotic scarring and edema causing mechanical blockage. While medical management with proton pump inhibitors and antibiotics treats the underlying ulcer disease, it does not relieve established obstruction. The primary treatment involves endoscopic balloon dilatation to mechanically open the narrowed pyloric channel. In cases where endoscopic treatment fails or is not feasible, surgical intervention such as antrectomy, gastrojejunostomy, or pyloroplasty is required to bypass or remove the obstruction. This approach directly relieves the obstruction and restores gastric emptying.

Reference: Harrison’s Principles of Internal Medicine, 20th Edition.