Patients with complete dentures generally prefer to chew tough foods in the premolar region because it provides an optimal balance between masticatory efficiency and denture stability. The premolar region offers a favorable lever arm for force application while minimizing denture dislodgment, unlike the molar region, which produces greater displacing forces due to its distal position. Furthermore, the premolars help maintain better denture retention and prevent tipping or rocking during mastication, enhancing patient comfort and function. Therefore, this region is most effective for managing tougher foods with complete dentures.

Reference: Prosthodontics, Sharry, D. R., 3rd Edition.