Prescribing unindicated drugs in chronic disease management is considered an irrational practice because it exposes patients to unnecessary medication risks, increases healthcare costs, and may lead to adverse drug reactions or drug interactions without providing clinical benefit. Effective management requires therapies to be evidence-based, targeted, and tailored to the patient's current condition. Inappropriate prescribing undermines treatment goals and can worsen patient outcomes. Therefore, avoiding unindicated drugs is essential for safe and rational chronic disease care.

Reference: Harrison's Principles of Internal Medicine, Jameson et al., 20th Edition.