The lateral border of the tongue is the most common site for oral squamous cell carcinoma due to its thin, non-keratinized mucosa and high exposure to carcinogens like tobacco and alcohol. This area has a rich lymphatic supply, facilitating early metastasis. Clinically, lesions here often present as ulcerative or exophytic growths, requiring careful surgical excision with clear margins to prevent local recurrence. Early recognition and biopsy of suspicious lesions on the lateral tongue are critical for improving prognosis. Reference: Oral and Maxillofacial Pathology, Neville et al., 4th Edition.