Ozone depletion leads to increased ultraviolet (UV) radiation reaching the Earth's surface. Higher UV exposure significantly elevates the risk of developing UV-related diseases, including skin cancers (basal cell carcinoma, squamous cell carcinoma, melanoma), cataracts, and immune system suppression. The ozone layer normally acts as a protective shield, absorbing most harmful UV-B rays. With its depletion, the body's natural defense is compromised, resulting in greater DNA damage in skin cells and heightened disease susceptibility. Therefore, ozone depletion correlates directly with increased incidence and severity of UV-induced health problems.

Reference: Harrison's Principles of Internal Medicine, Fauci et al., 20th Edition.