Severe falciparum malaria is characterized by high fever, severe anemia, and cerebral symptoms due to the extensive destruction of red blood cells and sequestration of parasitized erythrocytes in small blood vessels. These manifestations result in impaired tissue perfusion and organ dysfunction, particularly affecting the brain, leading to cerebral malaria. The presence of severe anemia worsens oxygen delivery, contributing to morbidity and mortality. These clinical features distinguish severe falciparum malaria from other milder or uncomplicated forms of the disease, requiring urgent treatment.

Reference: Harrison's Principles of Internal Medicine, Kasper et al., 20th Edition.