Paracoccidioidomycosis is a systemic fungal infection caused specifically by Paracoccidioides brasiliensis, a dimorphic fungus endemic to Latin America. This pathogen primarily affects the lungs but can disseminate to mucous membranes, skin, and lymph nodes. The diagnosis is confirmed by identifying the characteristic multiple budding yeast cells resembling a "pilot's wheel" in clinical specimens. Other fungi listed do not cause this disease. Effective treatment requires antifungal therapy targeted at this organism, emphasizing the importance of correct identification.

Reference: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Mandell et al., 9th Edition.