Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital-acquired infections due to its resistance to multiple antibiotics, making it difficult to treat. MRSA commonly colonizes the skin and nasal passages, facilitating transmission in healthcare settings. Its ability to survive on surfaces and invasive devices increases infection risk, especially in surgical wounds, catheters, and ventilators. Prompt identification and strict infection control measures are essential to prevent MRSA spread in hospitals, where vulnerable patients are at high risk. Other options are less commonly associated with nosocomial infections.

Reference: Medical Microbiology, Murray et al., 9th Edition.