The most appropriate response is to invite the patient to share their concerns and explain the risks and safety protocols in detail because this approach respects patient autonomy and promotes informed consent. Addressing the patient's anxiety by providing clear, honest information about potential risks and the measures in place to ensure safety helps build trust and reduce fear. Avoiding or dismissing questions can increase anxiety and undermine confidence in the care team. Effective communication about surgical risks is essential for ethical practice and enhances patient satisfaction and compliance.

Reference: Principles of Surgery, Schwartz, 11th Edition.