The classic presentation of appendicitis includes initial visceral pain around the umbilicus due to midgut innervation, which later localizes to the right lower quadrant (McBurney's point) as the parietal peritoneum becomes inflamed. This migratory pattern of pain is a key clinical feature that helps distinguish appendicitis from other causes of right lower abdominal pain, which typically do not show this specific migration. Identifying this pattern aids in early and accurate diagnosis, guiding timely surgical intervention to prevent complications like perforation.

Reference: Sabiston Textbook of Surgery, Courtney M. Townsend Jr., 21st Edition.