Which phase of the cell cycle occupies the greatest duration?

A Prophase

B Metaphase

C Interphase

D Telophase

Solution

Correct Answer: Option C

Interphase occupies the greatest duration of the cell cycle because it encompasses the period of cell growth and DNA replication necessary for cell division. During interphase, the cell performs essential metabolic activities, synthesizes proteins, and duplicates its DNA, preparing for mitosis. Unlike the shorter mitotic phases (prophase, metaphase, telophase), interphase ensures the cell is fully equipped to divide correctly. Clinically, understanding the length of interphase is crucial in targeting rapidly dividing cells in cancer therapy.

Reference: Molecular Biology of the Cell, Alberts et al., 6th Edition.

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